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Is Marfan Syndrome Associated with Symptomatic Intracranial Aneurysms? Stroke 27:10-12, van den Berg,J.S.P.,et al, 1996 See this aricle in Pubmed Article Abstract No patient visiting the Marfan clinic had a symptomatic intracranial aneurysm.No patient with Marfan syndrome had been admitted with a ruptured intracranial aneurysm at the departments of neurology or neurosurgery in the period,while during that period 826 patients with symptomatic intracranial aneurysm had been admitted.During follow-up of 129 of the 135 patients with Marfan syndrome(2850 retrospective patient observation years and 581 prospective patient observation years),none presented a symptomatic intracranial aneurysm.The suggested relationship between Marfan syndrome and intracranial aneurysms is based mainly on 10 case reports.However,diagnosis of Marfan syndrome is doubtful in several of these reports.Several large studies of patients with Marfan syndrome did not mention a ruptured intracranial aneurysm as a clinical manifestation. We conclude that there is insufficient evidence to presume a relationship between symptomatic intracranial aneurysms and Marfan syndrome on the basis of currently available data.

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